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Title: Regulation of Factor VII Activity by Serpins (Serine Protease Inhibitors) (Research Advisor: Dr. Frank C. Church, Biology Sponsor: Dr. Ellen Young, Research Mentor: Dr. Yolanda Fortenberry)
Anne Bouchelle Cook More than 50% of the American population will die from complications of thrombosis, or uncontrolled clot formation. Blood coagulation, or clotting, is essential for humans to survive daily damage to our fragile blood vessels. A cascade of events leads up to the final development of a platelet plug or clot in vessel walls. One protein in the cascade, factor VIIa, is known to be an integral part of the process, leading to the activation of factor X. I am studying the inhibition of factor VIIa by a variety of plasma derived protease inhibitors. |
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