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Title: Analysis of a Carcinogen-Based Mouse Model for Hepatocarcinogenesis (Advisor: David Threadgill, PhD - Sponsor: Dr. Al Baldwin, PhD - Mentor: Reade Roberts)
Benjamin Wood While the carcinogen azoxymethane (AOM) has historically been used to promote colon cancer development in mice, it has recently been found that AOM is also capable of inducing genetic background-dependent liver tumors in mice. The specific locations in the mouse genome determining susceptibility to liver cancer were revealed through correlation of tumor incidence with the particular strains of mice used in the analysis. The two highly significant regions that we have isolated as determining susceptibility to liver cancer in mice have also been strongly associated with the progression of liver cancer in humans. These findings suggest that the mouse liver tumors are representative of human cancer, indicating the possibility that a new mouse model for multiple types of human liver cancer may be developed |
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