|
Title: Probing Drosophila for insight into the clinically mild symptoms of xeroderma pigmentosum group F (Advisor: Dr. Jeff Sekelsky - Mentor: Ozlem Yildiz)
To maintain the integrity of DNA against constant assault from both environmental and physiological processes, all organisms have a collection of DNA repair pathways. One such pathway, Nucleotide Excision Repair (NER), is responsible for correcting ultraviolet light-induced damage. In humans, seven genes (XPA-XPG) are involved in NER, and people with defects in any one of these genes suffer from the disease Xeroderma pigmentosum (XP). Patients with defects in XPF, however, suffer from a much milder form of XP. Using Drosophila as a model organism, my research seeks to account for the milder phenotype of XPF, using this insight to elucidate NER |
|
|
