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Title: Molecular and Histological Characterization of Murine Epidermal Growth Factor Receptor Null Placentae (Advisor: Dr. David Threadgill - Sponsor: Dr. Jeff Dangl - Mentor: Dr. Karen Strunk)
The epidermal growth factor receptor (Egfr) is a molecule that plays a role in normal placental development and in formation of epithelial cancers. This project focuses on characterization of the Egfr in the placenta. An understanding of the Egfr in placental development is important because decreased human EGFR activity has been implicated in the pathological condition known as intrauterine growth retardation. Disruption of the Egfr gene in mice leads to abnormal placental architecture and an inability to support a developing embryo in some strains of mice, which is similar to the growth retardation observed in the human case |
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