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Title: Human Fucosyltransferases and Cancer Cell Growth (Advisor: Dr. Brent Weston - Sponsor: Dr. William Marzluff - Mentor: Dr. Paul Monahan)
Retinoic acid inhibits the growth of cancerous cells, including hepatocellular carcinoma (liver cancer). This is one of the most common and least curable cancers today. This study will explore the effects of retinoic acid on the enzyme fucosyltransferase 3. Past research has shown that the products of this enzyme are directly associated with tumor growth. We have developed methods of decreasing enzyme levels by 50-70% thus slowing tumor growth. Understanding how retinoic acid affects fucosyltransferase 3 will help in creating more effective anti-cancer treatments with fewer harmful side effects than available chemotherapies. |
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