|
Title: Functional Redundancy of Roc genes in Drosophila (Advisor: Dr. R. Duronio - Mentor: Dr. T. Donaldson)
Specific protein degradation involves a three-step process involving the activation, conjugation, and ligation of ubiquitin onto a particular protein. The SCF complex is a multi-subunit complex whose targets include regulators of cell-cycle transitions and components of signaling pathways. The SCF consists of four subunits: an F-box protein that binds the substrate, Skp1 that links the F-box/substrate to the Cul1 scaffold, and the RING domain protein Roc. Roc genes provide the catalytic core of the ubiquitin ligation by recruiting the addition of ubiquitin onto other ubiquitins to form a polyubiquitin chain. This project aims to figure out the extent of functional redundancy of the three Roc genes in Drosophila with hopes of gaining information of the role of the Roc genes in the SCF complex and their role in Drosophila biological processes. |
|
|
