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Title: The role of Protein C Inhibitor in Breast Cancer Cells (Advisor: Dr. Frank Church - Sponsor: Dr. Walter Bollenbacher - Mentor: Sophie Rehault)
I have examined the possible connection between cancer metastasis and Protein C Inhibitor (PCI), also known as plasminogen activator inhibitor 3 (PAI-3). Recent research claims that plasminogen activator inhibitor 1 (PAI-1), another similar serine protease inhibitor, retards apoptosis in tumor cells. The role of PCI in blood coagulation is very well known as the primary inhibitor of anti-coagulant activated protein C, but its function in the metastasis process is unclear. Some research hypothesized that PCI has a role in adhesion and migration of breast cancer cells. My project examines the regulation of breast cancer cell apoptosis induced by chemotherapeutic agents in the presence of PCI in order to further understand the role of this inhibitor in cancer |
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