Peifer CV

Mark Peifer's Curriculum Vitae

919-962-2271

919-962-1625 FAX

peifer@unc.edu

http://www.bio.unc.edu/faculty/peifer/

Ad-hoc Member, NIH CDF4 Study Section, 1999, 2003, 2004; NIH CDF-5 2002
NIH Program Project or Special Emphasis Panels: NIH/NCI 2000; CDF-5 2001; CDF2 2002; CBY SEP 2009

Presented the Keynote Lecture,Keystone Symposium, Intercellular Junctions February 2000

Publications
109. Homem, C.C.F., and Peifer, M. (2009). Exploring the roles of Diaphanous and Enabled activity in shaping the balance between filopodia and lamellipodia. Molecular Biology of the Cell, in press.

108. Sawyer, J.K, Harris, N. J, and Peifer, M. (2009) Morphogenesis: Multitalented GTPases seeking new jobs. Current Biology19, R985-987.

107. Roeth, J.F., Sayer, J.K., Wilner, D.A., and Peifer, M. (2009). Rab11 Helps Maintain Apical Crumbs and Adherens Junctionsin the Drosophila Embryonic Ectoderm. PLoS One 4 e7634.

106. Gates, J., ,Nowotarski,S.H., Yin, H., Mahaffey, J.P., Bridges, T., Herrera,C., Homem,C.C.F., Janody, F., Montell, D.J.and Peifer,M. (2009) Enabled and Capping protein play important roles in shaping cell behavior during Drosophila oogenesis. Developmental Biology 333, 90-107.

105. Cadigan, K.M., and Peifer, M. (2009) Wnt Signaling from Development to Disease: Insights from Model Systems. Cold Spring Harb Perspect Biol doi: 10.1101/cshperspect.a002881 in press

104. Sawyer, J.K., Harris, N.J., Slep, K.C., Gaul, U., and Peifer, M. (2009) The Drosophila afadin homolog Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction. Journal of Cell Biology 186, 57-73.

103. Harris, T.J.C., Sawyer, J.K., and Peifer, M. (2009). How the cytoskeleton helps build the embryonic body plan: Models of morphogenesis from Drosophila. Current Topics in Developmental Biology 89, 55-85.

102. Rogers,G.C., Rusan, N.M., Roberts,D.M., Peifer, M., and Rogers, S.L. (2009). The SCFSlimb ubiquitin-ligase regulates Plk4/Sak levels to block centriole reduplication. Journal of Cell Biology 184, 225-239.

101. Duncan, M.C., and Peifer, M. (2008). Regulating polarity by directing traffic: Cdc42 prevents adherens junctions from Crumblin’ aPart. Journal of Cell Biology 183: 971-974.

100. Rusan, N.M., Akong, K., and Peifer, M. (2008). Putting the model to the test: are APC proteins essential for neuronal polarity, axon outgrowth and axon targeting? Journal of Cell Biology 183, 203-212.

99. Rusan, N.M., and Peifer, M. (2008). Original CIN: reviewing roles for APC in chromosome instability. Journal of Cell Biology 181, 719-726.

98. Rogers, G.C., Rusan, N.M., Peifer, M.and Rogers, S.L. (2008). A Multi-Component Assembly Pathway Contributes to the Formation of Acentrosomal Microtubule Arrays in Interphase Drosophila cells. Molecular Biology of the Cell 19, 3163-3178.

97. Gottardi, C.J., and Peifer, M. (2008). Terminal regions of ß-catenin come into view. Structure 16, 336-338.

96. Homem, C.C.F., and Peifer, M. (2008) Diaphanous regulates myosin and adherens junctions to control cell contractility and protrusive behavior during morphogenesis. Development 135, 1005-1018.

95. Stevens, T L., Rogers, E M., Koontz, L. M. , Fox, D. T., Homem, C. C.F., Nowotarski, S. H., Artabazon, N. B., and Peifer, M. (2008). Using Bcr-Abl to examine mechanisms by which Abl kinase regulates morphogenesis in Drosophila. Molecular Biology of the Cell 19, 378-393.

94. Roberts, D.M., Slep, K.C., and Peifer, M. (2007). It takes more than two to tango: Dishevelled polymerization and Wnt signaling. Nature Structural and Molecular Biology 14, 463-465.

93. Gates, J., Mahaffey, J.P., Rogers, S.L., Emerson, M., Rogers, E.M., Sottile, S.L., Van Vactor, D., Gertler, F.B., and Peifer, M. (2007). Enabled plays key roles in Embryonic Epithelial Morphogenesis in Drosophila. Development 134, 2027-2039.

92. Harris, T.J.C., and Peifer, M. (2007). aPKC controls microtubule organization to balance adherens junction symmetry and planar polarity during development. Developmental Cell 12, 727-738.

91. Rusan, N.M., and Peifer, M. (2007). A role for a novel centrosome cycle in asymmetric cell division. Journal of Cell Biology 177, 13-20.

90. Hayden, M.A., Akong, K., and Peifer, M. (2007). Novel roles for APC family members and Wingless/Wnt signaling during Drosophila brain development. Developmental Biology 305, 358-376.

89. Fox, D.T., and Peifer, M. (2007). Abelson kinase and RhoGEF2 regulate actin organization during cell constriction in Drosophila. Development 134, 567-578.

88. Fox, D.T., and Peifer, M. (2007). Cell adhesion: Separation of p120's powers? Current Biology 17, R24-R27.

87. McCartney, B.M., Price, M.H., Webb, R., , Hayden, M.A., Holot, L., Zhou, M, Bejsovec, A., and Peifer, M. (2006). Testing hypotheses for the functions of APC family proteins using null and truncation alleles in Drosophila. Development 133 2407-2418.

86. Price, M.H., Roberts, D.M., McCartney, B.M., Jezuit, E., and Peifer, M. (2006). Cytoskeletal dynamics and cell signaling during planar polarity establishment in the Drosophila embryonic denticle. Journal of Cell Science 119: 403-415.

85. Gates, J., and Peifer, M. (2005). Can 1000 reviews be wrong? Actin, alpha-catenin and adherens junctions. Cell 123, 769-772.

84. Fox, D.T., Homem, C.C.F., Myster, S.H., Wang, F., Bain, E.E., and Peifer, M. (2005). Rho1 Regulates Drosophila Adherens Junctions Independently of p120ctn. Development, 132, 4819-4831.

83. Harris, T.J.C., and Peifer, M. (2005). The positioning and segregation of apical cues during epithelial polarity establishment in Drosophila. Journal of Cell Biology 170, 813-823.

82. McEwen, D.G., and Peifer, M. (2005). Puckered, a Drosophila MAPK phosphatase, ensures cell viability by antagonizing JNK-induced apoptosis. Development 132, 3935-3946.

80. Harris, T.J.C., and Peifer, M. (2004). Adherens junction-dependent and -independent steps in the establishment of epithelial cell polarity in Drosophila. Journal of Cell Biology165, 135-147.

79. Myster, S.H., Wang, F., Cavallo, R., Christian, W., Bhotika, S., Anderson, C.T., and Peifer, M. (2004). Genetic and bioinformatic analysis of 41C and the 2R heterochromatin of Drosophila melanogaster: A window on the heterochromatin-euchromatin junction. Genetics 166, 807-22.

78. Grevengoed, E.E., Fox, D.T., Gates, J., and Peifer, M. (2003). Balancing different types of actin polymerization at distinct sites: Roles for Abelson kinase and Enabled. Journal of Cell Biology 163, 1267-1280.

77. Peifer, M., and Yap, A.S. (2003). Traffic control: p120-catenin acts as a gatekeeper to control the fate of classical cadherins in mammalian cells. Journal of Cell Biology 163, 437-440.

76. McCartney, B.M., and Peifer, M. (2003). Stem Cells in the News: CNN and APC Make Headlines. Developmental Cell 5, 532-4.

75. Grevengoed, E.E., and Peifer, M. (2003). Cytoskeletal connections: Building strong cells in new ways. Current Biology 13, R568-70.

74. Myster, S.H.,, Cavallo, R., Anderson, C.T., Fox, D.T.. and Peifer, M. (2003). Drosophila p120catenin plays a supporting role in cell adhesion but is not an essential adherens junction component. Journal of Cell Biology 160, 433-449 .

73. Peifer, M. (2002). Developmental Biology: Colon construction. Nature 420 274-276.

72. Macara, I.G., Baldarelli, R., Field, C.M., Glotzer, M., Hayashi, Y., Hsu, S.-C., Kennedy, M.B., Kinoshita, M., Longtine, M., Low, C., Maltais, L.J., McKenzie, L., Mitchison, T.J., Nishikawa, T., Noda, M., Petty, E.M., Peifer, M., Pringle, J.R., Robinson, P.J., Roth, D., Russell, S.E.H., Stuhlmann, H., Tanaka, M., Tanaka, T., Trimble, W.S., Ware, J. Zeleznik-Le, N.J., Zieger, B. (2002). Mammalian septins nomenclature. Molecular Biology of the Cell 13, 4111-4113.

71.Akong, K., McCartney, B.M., and Peifer, M. (2002) Drosophila APC2 and APC1 have overlapping roles in the larval brain despite their distinct intracellular localizations. Developmental Biology 250, 71-90. 70. Akong, K., Grevengoed, E.E., Price, M.H., McCartney, B.M., Hayden, M.A., DeNofrio, J.C., and Peifer, M. (2002). Drosophila APC2 and APC1 play overlapping roles in Wingless signaling in the embryo and imaginal discs. Developmental Biology 250, 91-100.

69. Peifer, M., and McEwen, D.G. (2002). The ballet of morphogenesis: Identifying the hidden choreographers. Cell 109: 271-274.

68. Shih, H-P., Hales, K. G., Pringle, J.R., and Peifer, M. (2002). Identification of Septin-interacting Proteins and Characterization of the Smt3/SUMO-conjugation System in Drosophila. Journal of Cell Science 115, 1259-1271.

67. Grevengoed, E.E., Loureiro, J.J., Jesse, T.L., and Peifer, M. (2001). Abelson kinase regulates epithelial morphogenesis in Drosophila. Journal of Cell Biology 155, 1185-1197.

66. Myster, S.H., and Peifer, M. (2001) Wingless can't fly so it hitches a ride with dynein. Bioessays 23, 869-872.

65. McCartney, B.M., McEwen, D.G., Grevengoed,, E., Maddox, P., Bejsovec, A., Peifer, M. (2001) Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin. Nature Cell Biology 3, 933-938 .

64. McEwen, D.G., and Peifer, M. (2001) Wnt signaling: The Naked Truth? Current Biology 11: R524-R526.

63. Loureiro, J.J., Akong, K., Cayirlioglu, P., Baltus, A.E., DiAntonio, A., and Peifer, M. (2001) Activated Armadillo/beta-catenin does not play a general role in cell migration and process extension in Drosophila . Developmental Biology 235: 33-44.

62. Simcha, I., Kirkpatrick, C., Sadot, E., Shtutman, M. Polevoy, G., Geiger, B., Peifer, M., and Ben-Ze'ev, A. (2001). Cadherin Sequences that Inhibit beta-catenin Signaling: a Study in Yeast and Mammalian Cells. Molecular Biology of the Cell 12: 1177-88.

61. Tepass, U., Truong, K., Godt, D., Ikura, M., Peifer, M. (2000). Cadherins in embryonic and neural morphogenesis.. Nature Reviews: Molecular Cell Biology 1: 91-100.

60. Adam, J.C., Pringle, J.R., and Peifer, M. (2000). Evidence for functional differentiation among Drosophila septins in cytokinesis and cellularization. Molecular Biology of the Cell 11: 3123-3135.

59. Peifer, M. (2000). Travel bulletin: traffic jams cause tumors. Science 289, 67-69.

58. McEwen, D.G., Cox, R.T., and Peifer, M. (2000). The canonical Wg and JNK signaling cascades collaborate to promote both dorsal closure and ventral patterning. Development 127, 3607-3617.

57. McEwen, D.G., and Peifer, M. (2000). Wnt signaling: Moving in a new direction. Current Biology 10, R562-R564.

56. Cox, R.T., McEwen, D.G., Myster, D.G., Duronio, R.J., Loureiro, J., and Peifer, M. (2000). A screen for mutations that suppress the phenotype of Drosophila armadillo, the beta-catenin homolog. Genetics 155, 1725-1740.

55. McCartney, B.M., and Peifer, M. (2000). Teaching tumor suppressors new tricks. Nature Cell Biol. 2, E58-60.

54. Peifer, M., and Polakis, P. (2000). Wnt signaling in oncogenesis and embryogenesis: A look outside the nucleus. Science 287, 1606-1609.

53. Peifer, M., and Tepass, U. (2000). Cell Biology: Which way is up? Nature 403, 611-612.

52. McCartney, B., Dierick, H.A., Kirkpatrick, C., Moline, M.M., Baas, A., Peifer, M., and Bejsovec, A. (1999). Drosophila APC2 is a cytoskeletally-associated protein that regulates Wingless signaling in the embryonic epidermis. J. Cell Biol. 146, 1303-1318.

51. Peifer, M. (1999). Signal transduction: Neither straight nor narrow. Nature 400, 213-215.

50. Cox, R.T., Pai,, L.-M., Kirkpatrick, C., Stein,J., and Peifer, M. (1999). Roles of the C-terminus of Armadillo in Wingless signaling in Drosophila . Genetics,153, 319-332.

49. Cox, R.T., Pai, L.-M., Miller, J.R., Orsulic, S.,Stein,J., McCormick, C.A., Audeh, Y., Wang, W., Moon, R.T., and Peifer, M. (1999). Membrane-tethered Drosophila Armadillo cannot transduce Wingless signal on its own. Development 126, 1327-1335.

48. Lu, Q., Paredes, M., Medina, M., Zhou, J., Cavallo, R., Peifer, M., Orecchio, L. and Kosik, K.S. (1999). Delta-catenin, an adhesive junction-associated protein which promotes cell scattering. J. Cell Biol. 144, 519-532.

47. van Es, J.H., Kirkpatrick, C., van de Wetering, M., Molenaar, M., Miles, A., Kuipers, J. Destree, O., Peifer, M., and Clevers, H. (1999). Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor. Current Biology 9, 105-108.

46. Cavallo, R.A., Cox, R.T., Moline, M.M., Roose, J., Polevoy, G.A., Clevers, H., Peifer, M., and Bejsovec, A. (1998). Drosophila TCF and Groucho interact to repress Wingless signaling activity. Nature 395, 604-608.

45. Loureiro, J., and Peifer, M. (1998). The roles of Armadillo, a Drosophila catenin, during central nervous system development. Current Biology 8, 622-632.

43. Cox, R.T., and Peifer, M. (1998). Wingless/Wnt signaling: The inconvenient complexitites of life. Current Biology 8, R140-R144.

42. Pai, L.-M., Orsulic, S., Bejsovec, A. and Peifer, M. (1997). Negative regulation of Armadillo, a Wingless effector in Drosophila . Development 124, 2255-2266.

41. Cavallo, R., Rubenstein, D., and Peifer, M. (1997). Armadillo and dTCF: A marriage made in the nucleus. Curr. Opin. Genet. Devel. 7, 459-466.

40. van de Wetering, M., Cavallo, R., Dooijes, D., van Beest, M., van Es, J., Loureiro, J., Ypma, A., Hursh, D., Jones, T., Bejsovec, A., Peifer, M., Mortin, M., and Clevers, H. (1997). Armadillo co-activates transcription driven by the product of the Drosophila segment polarity gene dTCF . Cell 88, 789-799.

39. Peifer, M. (1997). Beta-catenin as oncogene-- the smoking gun. Science 275, 1752-1753.

38. Pai, L.-M., Kirkpatrick, C., Blanton, J., Oda, H., Takeichi, M., and Peifer, M. (1996). alpha -catenin and DE-cadherin occupy distinct binding sites on Drosophila Armadillo that differ substantially in size. J. Biol. Chem. 271, 32411-32420.

37. Orsulic, S., and Peifer, M. (1996). Wingless lands at last. Current Biology 6, 1363-1367.

36. Orsulic, S., and Peifer, M. (1996). An in vivo structure-function study of Armadillo, the beta-catenin homolog, reveals both separate and overlapping regions of the protein required for cell adhesion and for Wingless signaling. J. Cell Biol. 134, 1283-1301.

35. Cox, R., Kirkpatrick, C., and Peifer, M. (1996). Armadillo is required for adherens junction assembly, cell polarity and morphogenesis during Drosophila embryogenesis, J. Cell Biol. 134, 133-148.

34. Peifer, M. (1996). Regulating cell proliferation: as easy as APC (Perspective). Science 272, 974-975.

33. Bejsovec, A. and Peifer, M. (1996). The wingless/Wnt-1 signaling pathway - new insights into the cellular mechanisms of signal transduction. In: Advances in Developmental Biology Volume 4, p. 1-45 (P. Wassarman, ed.). JAI Press, Connecticut

32. Fares, H., Peifer, M., and Pringle, J.P. (1995). Localization and possible functions of Drosophila septins. Mol. Biol. Cell 6, 1843-1859.

31. Rauskolb, C., Smith, K., Peifer, M., and Wieschaus, E. (1995). extradenticle determines segmental identities throughout Drosophila development. Development 121, 3663-3673.

30. Peifer, M. (1995). Cell adhesion and signal transduction-- the Armadillo connection. Trends Cell Bio. 5, 224-229.

29. Kirkpatrick, C., and Peifer, M. (1995). Not just glue- cell-cell junctions as cellular signaling centers. Curr. Opin. Genet. Devel. 5, 56-65.

28. Peifer, M., Pai, L.-M., and Casey, M. (1994). Phosphorylation of the Drosophila adhesive junction protein Armadillo: roles for Wingless signal and Zeste white-3 kinase. Dev. Biol. 166, 543-556.

26. Peifer, M., Berg, S., and Reynolds, A.B. (1994). A repeating amino acid motif shared by proteins with diverse cellular roles. Cell 76, 789-791.

25. Peifer, M., Sweeton, D., Casey, M., and Wieschaus, E. (1994). wingless signal and Zeste-white 3 kinase trigger opposing changes in the intracellular distribution of Armadillo. Development 120, 369-380.

24. Orsulic, S., and Peifer, M. (1994). A method to stain nuclei of Drosophila for confocal microscopy. Biotechniques 16, 441-447.

23. Peifer, M. (1993). Cancer, catenins, and cuticle patterning: a complex connection. Science 262, 1667-1668.

22. Peifer, M., Orsulic, S., Pai, L.-M., and Loureiro, J. (1993). A model system for cell adhesion and signal transduction in Drosophila . 1993 Development Suppl. 163-176.

21. Rauskolb, C., Peifer, M., and Wieschaus, E. (1993). extradenticle , a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene PBX1. Cell 74, 1101-1112.

20. Peifer, M. (1993). The product of the Drosophila segment polarity gene armadillo is part of a multi-protein complex similar to the vertebrate adherens junction. J. Cell Science 105, 993-1000.

19. Peifer, M., Orsulic, S., Sweeton, D., and Wieschaus, E. (1993). A role for the Drosophila segment polarity gene armadillo in cell adhesion and cytoskeletal integrity during oogenesis. Development 118, 1191-1207.

18. Peifer, M., and Wieschaus, E. (1993). The Drosophila melanogaster segment polarity gene armadillo is highly conserved in sequence and expression in the house fly, Musca domestica. J. Mol. Evol.36, 224-233.

17. Peifer, M., McCrea, P., Green K., Wieschaus, E., and Gumbiner, B. (1992). The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties. J. Cell Biology 118, 681-691.

16. Peifer, M. and Bejsovec, A. (1992). Knowing your neighbors; cell interactions determine intrasegmental pattern in Drosophila . Trends in Genetics 8, 243-248.

15. Peifer, M., Rauskolb, C., Williams, M., Riggleman, B., and Wieschaus, E. (1991). The segment polarity gene armadillo affects the wingless signaling pathway in both embryonic and adult pattern formation. Development 111, 1028-1043.

14. Peifer, M., and Wieschaus, E. (1990). The segment polarity gene armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin. Cell 63, 1167-1178.

13. Peifer, M., and Wieschaus, E. (1990). Mutations in the Drosophila gene extradenticle affect the way specific homeodomain proteins regulate segmental identity. Genes Dev. 4: 1209-1223.

12. Simon, J., Peifer, M., Bender, W., and O'Connor, M. (1990). Regulatory elements of the bithorax complex that control expression along the anterior-posterior axis. EMBO J.4, 3945-3956.

11. O'Connor, M., Peifer, M., and Bender, W. (1989). Constructing large DNA segments in E. coli. Science 244: 1307-1312.

10. Bender, W., Simon, J., Karch, F., O'Connor, M.B., and Peifer, M. (1989). Segmental regulation of the Bithorax complex of Drosophila . In: Molecular Genetics of Early Drosophila & Mouse Development. (M. Cappechi, ed.). Cold Spring Harbor Laboratory Press, New York.

9. Peifer, M., and Bender, W. (1988). Sequences of the gypsy transposon of Drosophila necessary for its effects on adjacent genes. Proc. Nat. Acad. Sci. 85: 9650-9654.

8. Bender, W., and Peifer, M. (1987). Oncogenes take wing. (Minireview). Cell 50: 519-520.

7. Peifer, M., Karch, F., and Bender, W. (1987). The bithorax complex: control of segmental identity. (Review). Genes Dev. 1: 891-898.

6. Peifer, M., and Bender, W. (1986). The anterobithorax and bithorax mutations of the bithorax complex. EMBO J. 5: 2293-2303.

5. Bender, W., Weiffenbach, B., Karch, F., and Peifer, M. (1985) Domains of cis-interaction in the bithorax complex. Cold Spring Harbor Symp. Quant. Biol. 50: 173-180.

4. Karch, F., Weiffenbach, B., Peifer, M., Bender, W., Duncan, I., Celniker, S., Crosby, M., and Lewis, E.B. (1985). The abdominal region of the bithorax complex. Cell 43: 81-96.

3. Bender, W., Akam, M., Karch, F., Beachy, P.A., Peifer, M., Spierer, P., Lewis, E.B., and Hogness, D.S. (1983). Molecular genetics of the bithorax complex of Drosophila melanogaster . Science 221: 23-29.

2. Hu, N., Peifer, M., Heidecker, G., Messing, J., and Rubenstein, I. (1982). The primary structure of a genomic zein sequence of maize. EMBO J. 1: 1337-1342.

1. Geraghty, D., Peifer, M., Rubenstein, I., and Messing, J. (1981). The primary structure of a plant storage protein: zein. Nucleic Acid Res. 9: 5163-5174. link

Field, C.M., Al-Awar, O. , Rosenblatt, J., Wong, M.L., Alberts, B., and Mitchison, T.J. (1996). A purified Drosophila septin complex forms filaments and exhibits GTPase activity. J. Cell. Biol. 133, 605-616.

Adhesive junctions and signal transduction in Drosophila . NIH R01 GM47857. June 2008-May2012
(first funded in 1992). $1,297,268 total costs ($225,000 in direct costs this year)

A model system to study the tumor suppressor APC. NIH RO1 GM67236 September 2008-August 2012. $672,000 total direct costs

Equipment grant on which I was co-PI
High-Volume Confocal Imaging System. NIH/NCRR 1 S10 RR021055. July 2005-June 2006. Steven Crews PI, Mark Peifer and Bob Goldstein, co-PIs. $250,839 total and direct costs from the NIH plus ~$60,000 in University matching funds.

2008 Santa Cruz Developmental biology Meeting. NSF 0752937. April 2008-March 2009. $10,596 total and direct costs.

Other grants since 1992
Flies, T cells and cancer: the Armadillo connection. Human Frontier Science Program RG0294/1998-M.
Hans Clevers (Utrecht), Ken Kinzler (Johns Hopkins), and Mark Peifer were co-PIs.
December 1998-December 2002. $756,000 total direct costs for the three labs

Developing strategies to block §-catenin action in signaling and cell adhesion during carcinogenesis.
US Army Breast Cancer Research Program Combined IDEA and Career Development Award.
DAMD17-98-1-8223. June 1998-May 2002; $503,450 total costs

Adhesive junctions and signal transduction in Drosophila . NIH R01 GM47857. August 1992-July 1998.

Cytokinesis and other roles of septins in Drosophila. NIH R01 GM52606. John Pringle P.I., Mark Peifer, co-P.I. May 1995-April 2000 $667,051 total costs.

armadillo 's role in pattern formation during Drosophila segmentation, oogenesis, and eye development.
The Searle Scholars Program. May 1992- June 1995. $180,000 total costs

A model system for cell adhesion. North Carolina Biotechnology Center. January 1993-June 1994.
$40,000 total costs

A structure-function analysis of cell-cell adhesive junctions in Drosophila .
March of Dimes Birth Defects Foundation. July 1993- June 1995. $60,000 total costs.

Training grants of which I am a Member
Genetics Training Grant, NIH 5T32 GM07092, Bob Duronio P.I. (5 students mentored)

Cell and Molecular Biology Training Grant, NIH 1T32 GM08581, Sharon Milgram, P.I. (1 student mentored)

Developmental Biology Training Grant, NIH 1T32 HD046369, Terry Magnuson , P.I. (1 student mentored)

Lineberger Comprehensive Cancer Center Post-doctoral Training Program, Joseph Pagano, P.I.
(5 fellows mentored)

American Heart Association Predoctoral Fellowship Jessica Sawyer 2007-2009

Previous

NIH Postdoctoral fellowships.
           Julie Gates                   2003-2005
            Traci Jesse                   2001-2003
            Brooke McCartney      1998-2001

Don McEwen              1998-2001.
            Steve Myster,               1999-2002
            Karen Hales                1999-2002.

Postdoctoral fellowship, Canadian National Institutes of Health Research, Tony Harris, 2003-2006

Postdoctoral fellowship, National Science and Engineering Research Council of Canada, Tony Harris, 2002-2003

The Leukemia and Lymphoma Society Special Fellow Award. Brooke McCartney. 2001-2004

Senior Scholar Award, Leukemia and Lymphoma Society, Julie Gates 2005-2008

ARC (French Cancer Society) Postdoctoral Fellowship Venonique Morel 2001

U.S. Army Breast Cancer Training Program Predoctoral Fellowship. Rob Cavallo. 1998-2001.

Terry Fox Postdoctoral Fellowship, National Cancer Institute of Canada. Catherine Kirkpatrick. 1996-1998

Dermatology Foundation 1998 Leaders Society Clinical Career Development Award. David Rubenstein. 1998-2001

St. Olaf College, Northfield, MN	B.A. Biology 1980
Research Associate- The structure of zein genes in corn Lab of Dr. Irwin Rubenstein, Univ. of Minnesota, St. Paul, MN	1980-1981
Ph. D. Dissertation- Regulation of the bithorax complex Lab of Dr. Welcome Bender, Harvard University, Boston, MA	1981-1988 Ph.D. 1988 Biochemistry
Postdoctoral Fellow, Lab of Dr. Eric Wieschaus Princeton University, Princeton NJ	1988-1991 Developmental Genetics
Assistant Professor of Biology Associate Professor of Biology Professor of Biology George and Alice Welsh Distinguished Term Professor Hooker Distinguished Professor University of North Carolina-Chapel Hill	1992-1997 1997-2002 2002-present 2001-2006 July 2006-present