|
Mark Peifer's Curriculum Vitae
919-962-2271 919-962-1625 FAX peifer@unc.edu http://www.bio.unc.edu/faculty/peifer/
|
Primary appointment
Other appointments
Hooker Distinguished Professor Faculty Member
Department of Biology
Curriculum in Genetics and Mol. Biology
CB#3280, Coker Hall
University of North Carolina Member
Chapel Hill NC 27599-3280 Lineberger Comprehensive Cancer Center
Academic
and
research record
| St. Olaf College, Northfield, MN
|
B.A. Biology 1980 |
| Research Associate- The structure of zein genes
in corn Lab of Dr.
Irwin Rubenstein, Univ. of Minnesota, St. Paul, MN |
1980-1981 |
| Ph. D. Dissertation- Regulation of the bithorax complex Lab of Dr.
Welcome Bender, |
1981-1988 Ph.D. 1988 Biochemistry |
| Postdoctoral Fellow, Lab of Dr. Eric Wieschaus Princeton
University, Princeton NJ |
1988-1991 Developmental Genetics |
|
Assistant Professor of Biology Hooker Distinguished Professor University of North Carolina-Chapel Hill |
1992-1997 July 2006-present |
Fellowships, Awards
Editorial Board, Journal of Cell Biology 2001-present
Editorial Board, Journal of Cell Science 2006-present
Editorial Board, Developmental Biology 2007-present
Member, NIH CDF4/ICI Study Section 2004-present
Ad-hoc Member, NIH CDF4 Study Section, 1999, 2003, 2004;
NIH CDF-5 2002
NIH Program Project or Special Emphasis Panels: NIH/NCI 2000; CDF-5 2001;
CDF2 2002
George and Alice Welsh Distinguished
Term Professor
2001-2006
Presented the Keynote Lecture, February 2000
Keystone Symposium, Intercellular Junctions
Recipient of 1999 Phillip and Ruth Hettleman Prize for Artistic 1999
and Scholarly Achievements by Young Faculty at UNC-CH
US Army Breast Cancer Research Program 1998-2002
Career Development Award
Searle Scholar 1992-1995
National Institutes of Health Postdoctoral Fellowship 1988-1991
National Science Foundation Predoctoral Fellowship 1981-1984
Graduated Summa cum laude, Phi Beta Kappa, May 1980
and with Departmental Distinction in Biology
Publications
99. Rusan, N.M., and Peifer, M. (2008). Original CIN: reviewing roles for
APC in chromosome instability. Journal of Cell Biology, in press.
98. Rogers, G.C., Rusan, N.M., Peifer, M.and Rogers, S.L. (2008). A Multi-Component Assembly Pathway Contributes to the Formation of Acentrosomal Microtubule Arrays in Interphase Drosophila cells. Molecular Biology of the Cell, in press.
97. Gottardi, C.J., and Peifer, M. (2008). Terminal regions of ß-catenin come into view. Structure 16, 336-338.
96. Homem, C.C.F., and Peifer, M. (2008) Diaphanous regulates myosin and adherens junctions to control cell contractility and protrusive behavior during morphogenesis. Development 135, 1005-1018.
95. Stevens, T L., Rogers, E M., Koontz, L. M. , Fox, D. T., Homem, C. C.F., Nowotarski, S. H., Artabazon, N. B., and Peifer, M. (2008). Using Bcr-Abl to examine mechanisms by which Abl kinase regulates morphogenesis in Drosophila. Molecular Biology of the Cell 19, 378-393.
94. Roberts, D.M., Slep, K.C., and Peifer, M. (2007). It takes more than two to tango: Dishevelled polymerization and Wnt signaling. Nature Structural and Molecular Biology 14, 463-465.
93. Gates, J., Mahaffey, J.P., Rogers, S.L., Emerson, M., Rogers, E.M., Sottile, S.L., Van Vactor, D., Gertler, F.B., and Peifer, M. (2007). Enabled plays key roles in Embryonic Epithelial Morphogenesis in Drosophila. Development 134, 2027-2039.
92. Harris, T.J.C., and Peifer, M. (2007). aPKC controls microtubule organization to balance adherens junction symmetry and planar polarity during development. Developmental Cell 12, 727-738.
91. Rusan, N.M., and Peifer, M. (2007). A role for a novel centrosome cycle in asymmetric cell division. Journal of Cell Biology 177, 13-20.
90. Hayden, M.A., Akong, K., and Peifer, M. (2007). Novel roles for APC family members and Wingless/Wnt signaling during Drosophila brain development. Developmental Biology 305, 358-376.
89. Fox, D.T., and Peifer, M. (2007). Abelson kinase and RhoGEF2 regulate actin organization during cell constriction in Drosophila. Development 134, 567-578.
88. Fox, D.T., and Peifer, M. (2007). Cell adhesion: Separation of p120's powers? Current Biology 17, R24-R27.
87. McCartney, B.M., Price, M.H., Webb, R., , Hayden, M.A., Holot, L., Zhou, M, Bejsovec, A., and Peifer, M. (2006). Testing hypotheses for the functions of APC family proteins using null and truncation alleles in Drosophila. Development 133 2407-2418.
86. Price, M.H., Roberts, D.M., McCartney, B.M., Jezuit, E., and Peifer, M. (2006). Cytoskeletal dynamics and cell signaling during planar polarity establishment in the Drosophila embryonic denticle. Journal of Cell Science 119: 403-415.
85. Gates, J., and Peifer, M. (2005). Can 1000 reviews be wrong? Actin, alpha-catenin and adherens junctions. Cell 123, 769-772.
84. Fox, D.T., Homem, C.C.F., Myster, S.H., Wang, F., Bain, E.E., and Peifer, M. (2005). Rho1 Regulates Drosophila Adherens Junctions Independently of p120ctn. Development, 132, 4819-4831.
83. Harris, T.J.C., and Peifer, M. (2005). The positioning and segregation of apical cues during epithelial polarity establishment in Drosophila. Journal of Cell Biology 170, 813-823.
82. McEwen, D.G., and Peifer, M. (2005). Puckered, a Drosophila MAPK phosphatase, ensures cell viability by antagonizing JNK-induced apoptosis. Development 132, 3935-3946.
80. Harris, T.J.C., and Peifer, M. (2004). Adherens junction-dependent and -independent steps in the establishment of epithelial cell polarity in Drosophila. Journal of Cell Biology165, 135-147.
79. Myster, S.H., Wang, F., Cavallo, R., Christian, W., Bhotika, S., Anderson, C.T., and Peifer, M. (2004). Genetic and bioinformatic analysis of 41C and the 2R heterochromatin of Drosophila melanogaster: A window on the heterochromatin-euchromatin junction. Genetics 166, 807-22.
78. Grevengoed, E.E., Fox, D.T., Gates, J., and Peifer, M. (2003). Balancing different types of actin polymerization at distinct sites: Roles for Abelson kinase and Enabled. Journal of Cell Biology 163, 1267-1280.
77. Peifer, M., and Yap, A.S. (2003). Traffic control: p120-catenin acts as a gatekeeper to control the fate of classical cadherins in mammalian cells. Journal of Cell Biology 163, 437-440.
76. McCartney, B.M., and Peifer, M. (2003). Stem Cells in the News: CNN and APC Make Headlines. Developmental Cell 5, 532-4.
75. Grevengoed, E.E., and Peifer, M. (2003). Cytoskeletal connections:
Building strong cells in new ways. Current Biology
13, R568-70.
74. Myster, S.H.,, Cavallo, R., Anderson, C.T., Fox, D.T.. and
Peifer, M. (2003). Drosophila p120catenin
plays a supporting role in cell adhesion but is not an essential
adherens junction component. Journal of
Cell Biology 160, 433-449 .
73. Peifer, M. (2002). Developmental Biology: Colon construction. Nature 420 274-276.
72. Macara, I.G., Baldarelli, R., Field, C.M., Glotzer, M.,
Hayashi,
Y., Hsu, S.-C., Kennedy, M.B., Kinoshita, M., Longtine, M., Low, C.,
Maltais, L.J., McKenzie, L., Mitchison, T.J., Nishikawa, T., Noda, M.,
Petty, E.M., Peifer, M., Pringle, J.R., Robinson, P.J., Roth, D.,
Russell, S.E.H., Stuhlmann, H., Tanaka, M., Tanaka, T., Trimble, W.S.,
Ware, J. Zeleznik-Le, N.J.,
Zieger, B. (2002). Mammalian
septins nomenclature. Molecular
Biology of the Cell 13, 4111-4113.
71.Akong, K., McCartney, B.M., and Peifer, M. (2002) Drosophila APC2 and APC1 have overlapping roles in the larval brain despite their distinct intracellular localizations. Developmental Biology 250, 71-90. 70. Akong, K., Grevengoed, E.E., Price, M.H., McCartney, B.M., Hayden, M.A., DeNofrio, J.C., and Peifer, M. (2002). Drosophila APC2 and APC1 play overlapping roles in Wingless signaling in the embryo and imaginal discs. Developmental Biology 250, 91-100.
69. Peifer, M., and McEwen, D.G. (2002). The ballet of morphogenesis: Identifying the hidden choreographers. Cell 109: 271-274.
68. Shih, H-P., Hales, K. G., Pringle, J.R., and Peifer, M. (2002). Identification of Septin-interacting Proteins and Characterization of the Smt3/SUMO-conjugation System in Drosophila. Journal of Cell Science 115, 1259-1271.
67. Grevengoed, E.E., Loureiro, J.J., Jesse, T.L., and Peifer, M. (2001). Abelson kinase regulates epithelial morphogenesis in Drosophila. Journal of Cell Biology 155, 1185-1197.
66. Myster, S.H., and Peifer, M. (2001) Wingless can't fly so it hitches a ride with dynein. Bioessays 23, 869-872.
65. McCartney, B.M., McEwen, D.G., Grevengoed,, E., Maddox, P., Bejsovec, A., Peifer, M. (2001) Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin. Nature Cell Biology 3, 933-938 .
64. McEwen,
D.G., and Peifer, M. (2001)
Wnt signaling: The Naked Truth?
Current Biology 11: R524-R526.
63. Loureiro,
J.J., Akong, K., Cayirlioglu, P., Baltus, A.E., DiAntonio, A., and Peifer, M. (2001) Activated
Armadillo/beta-catenin does not play a general role in cell migration
and process extension in Drosophila . Developmental
Biology
235: 33-44.
62. Simcha, I., Kirkpatrick, C., Sadot, E., Shtutman, M. Polevoy, G., Geiger, B., Peifer, M., and Ben-Ze'ev, A. (2001). Cadherin Sequences that Inhibit beta-catenin Signaling: a Study in Yeast and Mammalian Cells. Molecular Biology of the Cell 12: 1177-88.
61. Tepass, U., Truong, K., Godt, D., Ikura, M., Peifer, M. (2000). Cadherins in embryonic and neural morphogenesis.. Nature Reviews: Molecular Cell Biology 1: 91-100.
60. Adam, J.C., Pringle, J.R., and Peifer, M. (2000). Evidence for functional differentiation among Drosophila septins in cytokinesis and cellularization. Molecular Biology of the Cell 11: 3123-3135.
59. Peifer, M. (2000). Travel bulletin: traffic jams cause tumors. Science 289, 67-69.
58. McEwen, D.G., Cox, R.T., and Peifer, M. (2000). The canonical Wg and JNK signaling cascades collaborate to promote both dorsal closure and ventral patterning. Development 127, 3607-3617.
57. McEwen, D.G., and Peifer, M. (2000). Wnt signaling: Moving in a new direction. Current Biology 10, R562-R564.
56. Cox, R.T., McEwen, D.G., Myster, D.G., Duronio, R.J., Loureiro, J., and Peifer, M. (2000). A screen for mutations that suppress the phenotype of Drosophila armadillo, the beta-catenin homolog. Genetics 155, 1725-1740.
55. McCartney, B.M., and Peifer, M. (2000). Teaching tumor suppressors new tricks. Nature Cell Biol. 2, E58-60.
54. Peifer, M., and Polakis, P. (2000). Wnt signaling in oncogenesis and embryogenesis: A look outside the nucleus. Science 287, 1606-1609.
53. Peifer, M., and Tepass, U. (2000). Cell Biology: Which way is up? Nature 403, 611-612.
52. McCartney, B., Dierick, H.A., Kirkpatrick, C., Moline, M.M., Baas, A., Peifer, M., and Bejsovec, A. (1999). Drosophila APC2 is a cytoskeletally-associated protein that regulates Wingless signaling in the embryonic epidermis. J. Cell Biol. 146, 1303-1318.
51. Peifer, M. (1999). Signal transduction: Neither straight nor narrow. Nature 400, 213-215.
50. Cox, R.T., Pai,, L.-M., Kirkpatrick, C., Stein,J., and Peifer, M. (1999). Roles of the C-terminus of Armadillo in Wingless signaling in Drosophila . Genetics,153, 319-332.
49. Cox, R.T., Pai, L.-M., Miller, J.R., Orsulic, S.,Stein,J., McCormick, C.A., Audeh, Y., Wang, W., Moon, R.T., and Peifer, M. (1999). Membrane-tethered Drosophila Armadillo cannot transduce Wingless signal on its own. Development 126, 1327-1335.
48. Lu, Q., Paredes, M., Medina, M., Zhou, J., Cavallo, R., Peifer, M., Orecchio, L. and Kosik, K.S. (1999). Delta-catenin, an adhesive junction-associated protein which promotes cell scattering. J. Cell Biol. 144, 519-532.
47. van Es, J.H., Kirkpatrick, C., van de Wetering, M., Molenaar, M., Miles, A., Kuipers, J. Destree, O., Peifer, M., and Clevers, H. (1999). Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor. Current Biology 9, 105-108.
46. Cavallo, R.A., Cox, R.T., Moline, M.M., Roose, J., Polevoy,
G.A., Clevers, H., Peifer, M., and Bejsovec, A.
(1998). Drosophila TCF and Groucho interact to repress
Wingless signaling activity. Nature 395,
604-608.
45. Loureiro, J., and Peifer, M. (1998). The roles of Armadillo, a Drosophila catenin, during central nervous system development. Current Biology 8, 622-632.
44. Peifer, M. (1998). Birds of a feather flock together. Nature 395, 324-325.
43. Cox, R.T., and Peifer, M. (1998). Wingless/Wnt signaling: The inconvenient complexitites of life. Current Biology 8, R140-R144.
42. Pai, L.-M., Orsulic, S., Bejsovec, A. and Peifer, M. (1997). Negative regulation of Armadillo, a Wingless effector in Drosophila . Development 124, 2255-2266.
41. Cavallo, R., Rubenstein, D., and Peifer, M. (1997). Armadillo and dTCF: A marriage made in the nucleus. Curr. Opin. Genet. Devel. 7, 459-466.
40. van de Wetering, M., Cavallo, R., Dooijes, D., van Beest, M., van Es, J., Loureiro, J., Ypma, A., Hursh, D., Jones, T., Bejsovec, A., Peifer, M., Mortin, M., and Clevers, H. (1997). Armadillo co-activates transcription driven by the product of the Drosophila segment polarity gene dTCF . Cell 88, 789-799.
39. Peifer, M. (1997).
Beta-catenin as oncogene-- the smoking gun.
Science 275, 1752-1753.
38. Pai, L.-M., Kirkpatrick, C., Blanton, J., Oda, H., Takeichi, M., and Peifer, M. (1996). alpha -catenin and DE-cadherin occupy distinct binding sites on Drosophila Armadillo that differ substantially in size. J. Biol. Chem. 271, 32411-32420.
37. Orsulic, S., and Peifer, M. (1996). Wingless lands at last. Current Biology 6, 1363-1367.
36. Orsulic, S., and Peifer, M. (1996). An in vivo structure-function study of Armadillo, the beta-catenin homolog, reveals both separate and overlapping regions of the protein required for cell adhesion and for Wingless signaling. J. Cell Biol. 134, 1283-1301.
35. Cox, R., Kirkpatrick, C., and Peifer, M. (1996). Armadillo is required for adherens junction assembly, cell polarity and morphogenesis during Drosophila embryogenesis, J. Cell Biol. 134, 133-148.
34. Peifer, M. (1996). Regulating cell proliferation: as easy as APC (Perspective). Science 272, 974-975.
33. Bejsovec, A. and Peifer, M. (1996). The wingless/Wnt-1 signaling pathway - new insights into the cellular mechanisms of signal transduction. In: Advances in Developmental Biology Volume 4, p. 1-45 (P. Wassarman, ed.). JAI Press, Connecticut
32. Fares, H., Peifer, M., and Pringle, J.P. (1995). Localization and possible functions of Drosophila septins. Mol. Biol. Cell 6, 1843-1859.
31. Rauskolb, C., Smith, K., Peifer, M., and Wieschaus, E. (1995). extradenticle determines segmental identities throughout Drosophila development. Development 121, 3663-3673.
30. Peifer, M. (1995). Cell adhesion and signal transduction-- the Armadillo connection. Trends Cell Bio. 5, 224-229.
29. Kirkpatrick, C., and Peifer, M. (1995). Not just glue- cell-cell junctions as cellular signaling centers. Curr. Opin. Genet. Devel. 5, 56-65.
28. Peifer, M., Pai, L.-M., and Casey, M. (1994). Phosphorylation of the Drosophila adhesive junction protein Armadillo: roles for Wingless signal and Zeste white-3 kinase. Dev. Biol. 166, 543-556.
27. Peifer, M. (1994). The two faces of Hedgehog. Science 266, 1492-1493.
26. Peifer, M., Berg, S., and Reynolds, A.B. (1994). A repeating amino acid motif shared by proteins with diverse cellular roles. Cell 76, 789-791.
25. Peifer, M., Sweeton, D., Casey, M., and Wieschaus, E. (1994). wingless signal and Zeste-white 3 kinase trigger opposing changes in the intracellular distribution of Armadillo. Development 120, 369-380.
24. Orsulic, S., and Peifer, M. (1994). A method to stain nuclei of Drosophila for confocal microscopy. Biotechniques 16, 441-447.
23. Peifer, M. (1993). Cancer, catenins, and cuticle patterning: a complex connection. Science 262, 1667-1668.
22. Peifer, M., Orsulic, S., Pai, L.-M., and Loureiro, J. (1993). A model system for cell adhesion and signal transduction in Drosophila . 1993 Development Suppl. 163-176.
21. Rauskolb, C., Peifer, M., and Wieschaus, E. (1993). extradenticle , a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene PBX1. Cell 74, 1101-1112.
20. Peifer, M. (1993). The product of the Drosophila segment polarity gene armadillo is part of a multi-protein complex similar to the vertebrate adherens junction. J. Cell Science 105, 993-1000.
19. Peifer, M., Orsulic, S., Sweeton, D., and Wieschaus, E. (1993). A role for the Drosophila segment polarity gene armadillo in cell adhesion and cytoskeletal integrity during oogenesis. Development 118, 1191-1207.
18. Peifer, M., and Wieschaus, E. (1993). The Drosophila melanogaster segment polarity gene armadillo is highly conserved in sequence and expression in the house fly, Musca domestica. J. Mol. Evol.36, 224-233.
17. Peifer, M., McCrea, P., Green K., Wieschaus, E., and Gumbiner, B. (1992). The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties. J. Cell Biology 118, 681-691.
16. Peifer, M. and Bejsovec, A. (1992). Knowing your neighbors; cell interactions determine intrasegmental pattern in Drosophila . Trends in Genetics 8, 243-248.
15. Peifer, M., Rauskolb, C., Williams, M., Riggleman, B., and Wieschaus, E. (1991). The segment polarity gene armadillo affects the wingless signaling pathway in both embryonic and adult pattern formation. Development 111, 1028-1043.
14. Peifer, M., and Wieschaus, E. (1990). The segment polarity gene armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin. Cell 63, 1167-1178.
13. Peifer, M., and Wieschaus, E. (1990). Mutations in the Drosophila gene extradenticle affect the way specific homeodomain proteins regulate segmental identity. Genes Dev. 4: 1209-1223.
12. Simon, J., Peifer, M., Bender, W., and O'Connor, M. (1990). Regulatory elements of the bithorax complex that control expression along the anterior-posterior axis. EMBO J.4, 3945-3956.
11. O'Connor, M., Peifer, M., and Bender, W. (1989). Constructing large DNA segments in E. coli. Science 244: 1307-1312.
10. Bender, W., Simon, J., Karch, F., O'Connor, M.B., and Peifer, M. (1989). Segmental regulation of the Bithorax complex of Drosophila . In: Molecular Genetics of Early Drosophila & Mouse Development. (M. Cappechi, ed.). Cold Spring Harbor Laboratory Press, New York.
9. Peifer, M., and Bender, W. (1988). Sequences of the gypsy transposon of Drosophila necessary for its effects on adjacent genes. Proc. Nat. Acad. Sci. 85: 9650-9654.
8. Bender, W., and Peifer, M. (1987). Oncogenes take wing. (Minireview). Cell 50: 519-520.
7. Peifer, M., Karch, F., and Bender, W. (1987). The bithorax complex: control of segmental identity. (Review). Genes Dev. 1: 891-898.
6. Peifer, M., and Bender, W. (1986). The anterobithorax and bithorax mutations of the bithorax complex. EMBO J. 5: 2293-2303.
5. Bender, W., Weiffenbach, B., Karch, F., and Peifer, M. (1985) Domains of cis-interaction in the bithorax complex. Cold Spring Harbor Symp. Quant. Biol. 50: 173-180.
4. Karch, F., Weiffenbach, B., Peifer, M., Bender, W., Duncan, I., Celniker, S., Crosby, M., and Lewis, E.B. (1985). The abdominal region of the bithorax complex. Cell 43: 81-96.
3. Bender, W., Akam, M., Karch, F., Beachy, P.A., Peifer, M., Spierer, P., Lewis, E.B., and Hogness, D.S. (1983). Molecular genetics of the bithorax complex of Drosophila melanogaster . Science 221: 23-29.
2. Hu, N., Peifer, M., Heidecker, G., Messing, J., and Rubenstein, I. (1982). The primary structure of a genomic zein sequence of maize. EMBO J. 1: 1337-1342.
1. Geraghty, D., Peifer, M., Rubenstein, I., and Messing, J. (1981). The primary structure of a plant storage protein: zein. Nucleic Acid Res. 9: 5163-5174. link
Other publications by students under my supervision
Field, C.M., Al-Awar, O. , Rosenblatt, J., Wong, M.L., Alberts, B., and Mitchison, T.J. (1996). A purified Drosophila septin complex forms filaments and exhibits GTPase activity. J. Cell. Biol. 133, 605-616.
Loureiro, J. J. (1999). The Wnts (Gazetteer). Current Biology 9, R4.
Adhesive junctions and signal transduction in Drosophila . NIH R01 GM47857.
January 2004-December 2007
(first funded in 1992). $1,297,268 total
costs ($225,000 in direct costs this year)
A model system to study the tumor suppressor APC.
NIH RO1 GM67236 September 2002-August 2007. $672,000 total direct costs
Equipment grant on which I was co-PI
High-Volume Confocal Imaging System. NIH/NCRR 1 S10 RR021055.
July 2005-June 2006. Steven Crews
PI, Mark Peifer and Bob Goldstein, co-PIs. $250,839 total and direct
costs from the NIH plus ~$60,000 in University matching funds.
Lineberger Comprehensive Cancer Center Post-doctoral Training
Program, Joseph Pagano, P.I.
(5 fellows mentored)
Senior Scholar Award, Leukemia and Lymphoma Society, Julie Gates 2005-present
NIH Postdoctoral fellowships.
David Roberts
2006-2008
Jeremiah
Roeth 2006-2008
ACS Postdoctoral Fellowship,
Nasser Rusan, 2006-2009
Previous
NIH Postdoctoral fellowships.
Julie Gates
2003-2005
Traci Jesse
2001-2003
Brooke McCartney 1998-2001
Don McEwen
1998-2001.
Steve Myster,
1999-2002
Karen Hales
1999-2002.
Postdoctoral fellowship, Canadian National Institutes of Health Research,
Tony Harris, 2003-2006
Postdoctoral fellowship, National Science and Engineering Research Council of Canada, Tony Harris, 2002-2003