Bio 270 Developmental Genetics

Fall 2005

Mondays 3:30-5:00 pm Fordham 512

(except Friday Sept. 9 and Friday Nov. 18)

Mark Peifer (peifer@unc.edu; 2-2271)

and Vicki Bautch (bautch@med.unc.edu; 6-6797)

http://www.bio.unc.edu/faculty/peifer/documents/Bio270-2005.htm

Week 1 Friday September 9 Mark Peifer

Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos.

Tao Q, Yokota C, Puck H, Kofron M, Birsoy B, Yan D, Asashima M, Wylie CC, Lin X, Heasman J.

Cell. 2005 120:857-71.

Associated review: Axis formation--beta-catenin catches a Wnt.

Jessen, J.R., Solnica-Krezel, L. (2005).Cell 120:736-7

Week 2 Monday September 12 Vicki Bautch

The role of GDNF/Ret Signaling in uretic bud cell fate and branching morphogenesis.

Shakya, R. et al. (2005). Dev. Cell 8, 65-74.

Week 3 September 19 Sarah Taylor

Essential role of non-canonical Wnt signalling in neural crest migration.

De Calisto, J., Araya, C., Marchant, L., Riaz, C., and Mayor, R. (2005) Development 132, 2587-2597.

Week 4 September 26 Jacob Sawyer

Shroom induces apical constriction and is required for hingepoint formation during neural tube closure.

Haigo SL, Hildebrand JD, Harland RM, Wallingford JB. (2003) Curr Biol. 13:2125-37

Week 5 October 3 Anne White

Production of gurken in the nurse cells is sufficient for axis determination in the Drosophila oocyte.

Lucia Caceres and Laura A. Nilson. 2005. Development. 132(10): 2345-53.

Week 6 October10 Catarina Homem

A Rho GTPase Signaling Pathway Is Used Reiteratively in Epithelial Folding

and Potentially Selects the Outcome of Rho Activation
Kelly K. Nikolaidou1,3 and Kathy Barrett (2004) Current Biology, Vol. 14, 1822?1826, 2004.

No class week of October 17-21 FALL BREAK

Week 7 October 24 Jacquie de Marchena

Area specificity and topography of thalamocortical projections are controlled by ephrin/Eph genes.

Dufour A, Seibt J, Passante L, Depaepe V, Ciossek T, Frisen J,

Kullander K, Flanagan JG, Polleux F, Vanderhaeghen P.

(2003) Neuron. 39:453-65.

Week 8 October 31 Carrie Bacon

Wnt signalling inhibits neural differentiation of embryonic stem cells

by controlling bone morphogenetic protein expression.

Haegele L, Ingold B, Naumann H, Tabatabai G, Ledermann B, Brandner S.

Mol Cell Neurosci. 2003 Nov;24(3):696-708

Week 9 November 7 Lena Randhawa

roundabout4 is essential for angiogenesis in vivo

Victoria M. Bedell, Sang-Yeob Yeo, Kye Won Park, Jeffrey Chung,

Pankaj Seth, Venkatesha Shivalingappa, Jinhua Zhao, Tomoko Obara,

Vikas P. Sukhatme, Iain A. Drummond, Dean Y. Li, and Ramani Ramchandran

(2005) PNAS 102: 6373–6378

Week 10 Friday November 18 Joanna Fried

Angiopoietin 1 causes vessel enlargement, without angiogenic sprouting, during a critical developmental period.

Thurston, G., Q. Wang, F. Baffert, J. Rudge, N. Papadopoulos, D. Jean-Guillaume, S.

Wiegand, G.D. Yancopoulos, and D.M. McDonald.

2005. Development. 132:3317-3326.

No class week of November 21-25 THANKSGIVING

Week 11 November 28 Andrea Gossett

OPA1 requires mitofusin 1 to promote mitochondrial fusion.

Cipolat ,S., Martins de Brito, O., Dal Zilio, B., and L. Scorrano PNAS 2004 101:15927-32

Week 12 December 5 YEAR END REVIEW