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The Goldstein Lab
C. elegans	Tardigrades	People	Publications	Positions	Contact

Coming Soon:

Edgar, L.G. and B. Goldstein. Blastomere Culture and Manipulation. Methods in Cell Biology (in press).

McCarthy EK and B. Goldstein. Mitotic Progression Times Spindle Positioning During an Asymmetric Cell Division (submitted).

Marston, D.J., M. Roh, A. Mikels, R. Nusse, and B. Goldstein (2009) Wnt signaling during C. elegans embryonic development. Methods in Molecular Biology 469 (in press).

Published Articles and Reviews:

Goldstein, B. and I.G. Macara (2007) The PAR Proteins: Fundamental Players in Animal Cell Polarization. Developmental Cell 13:609-622.
		Gabriel, W.N., R. McNuff, S.K. Patel, T.R. Gregory, W.R. Jeck, C.D. Jones and B. Goldstein (2007) The Tardigrade Hypsibius dujardini, a New Model for Studying the Evolution of Development. Developmental Biology 312:545-559.
		Gabriel, W.N. and B. Goldstein (2007) Segmental Expression of Pax3/7 and Engrailed Homologs in Tardigrade Development. Development Genes and Evolution 217: 421-433.
Marston, D.J. and B. Goldstein (2006) Symmetry Breaking in C. elegans: Another Gift from the Sperm. Developmental Cell 11: 273-274.
		Lee, J.-Y., D.J. Marston, T. Walston, J. Hardin, A. Halberstadt and B. Goldstein (2006) Wnt/Frizzled Signaling Controls C. elegans Gastrulation by Activating Actomyosin Contractility. Current Biology 16: 1986-1997. (*equal contributors)
Marston, D.J. and B. Goldstein (2006) Actin-based forces driving embryonic morphogenesis in C. elegans. Current Opinion in Genetics and Development 16: 392-398.
		Goldstein B., H. Takeshita, K. Mizumoto and H. Sawa (2006) Wnt Signals Can Function as Positional Cues in Establishing Cell Polarity. Developmental Cell 10: 391-396. (*equal contributors) Lay Summary
McCarthy, E.K. and B. Goldstein (2006) Asymmetric Spindle Positioning. Current Opinion in Cell Biology 18: 79-85.
Nance, J., J.-Y. Lee and B. Goldstein (2005) Gastrulation in C. elegans, WormBook, ed. The C. elegans Research Community.
McCarthy, E.K. and B. Goldstein (2005) Asymmetric Division: A Kinesin for Spindle Positioning. Current Biology 15: R591-593.
Dudley, N.R., A.Z. Amin and B. Goldstein (2005) Genes Required for RNA Interference, pp 55-68 in RNA Interference Technology: From Basic Science to Drug Development, edited by K. Appasani (Cambridge University Press).
Dudley, N.R. and B. Goldstein (2005) RNA Interference in Caenorhabditis elegans. Chapter in RNA Silencing: Methods and Protocols, edited by G. Carmichael (Humana Press), Methods in Molecular Biology 309:29-38.
		Labbé, J.-C., E. McCarthy and B. Goldstein (2004) The forces that position a mitotic spindle asymmetrically are tethered until after the time of spindle assembly. The Journal of Cell Biology 167: 245-256.
		Cheeks, R.J., J.C. Canman, W.N. Gabriel, N. Meyer, S. Strome and B. Goldstein (2004) C. elegans PAR Proteins Function by Mobilizing and Stabilizing Asymmetrically Localized Protein Complexes. Current Biology 14: 851-862.
Goldstein, B. (2003) Asymmetric Division: AGS Proteins Position the Spindle. Current Biology 13: R879-R880.
		Labbé, J.-C., P.S. Maddox, E.D. Salmon, and B. Goldstein (2003) PAR proteins regulate microtubule dynamics at the cell cortex in C. elegans. Current Biology 13: 707-714.
		Lee, J.-Y. and B. Goldstein (2003) Mechanisms of cell positioning during C. elegans gastrulation. Development 130: 307-320.
Dudley, N.R. and B. Goldstein (2003) RNA interference: Silencing in the cytoplasm and nucleus. Curr Opin Mol Ther 5:113-117.
		Dudley, N.R., J.-C. Labbé, and B. Goldstein (2002) Using RNA Interference to Identify Genes Required for RNA Interference. PNAS 99:4191-4196.
Labbé, J.-C. and B. Goldstein (2002) Embryonic Development: A New SPN on Cell Fate Specification. Current Biology 12:R396-R398.
Goldstein, B. and M. Blaxter (2002) Tardigrades. Current Biology 12: R475.
Goldstein, B. (2001) On the Evolution of Early Development in the Nematoda. Phil Trans Royal Society B 356: 1521-31.
		Goldstein, B., M. Leviten and D. A. Weisblat (2001) Dorsal and Snail homologs in leech development. Development Genes and Evolution 211: 329-337.
Goldstein B. (2000) The Professional Debunker (review of the book Voodoo Science: the Road from Foolishness to Fraud, by Robert L. Park), Nature Cell Biology 2:E212.
Goldstein, B. (2000) Embryonic polarity: A role for microtubules. Current Biology 10:R820-R822.
Goldstein, B. (2000) When cells tell their neighbors which direction to divide. Developmental Dynamics 218:23-29.
		Goldstein, B., L. Frisse and W. K. Thomas (1998) Embryonic axis specification in nematodes: evolution of the first step in development. Current Biology 8: 157-160.
		Wittmann, C., O. Bossinger, B. Goldstein, M. Fleischmann, R. Kohler, K. Brunschwig, H. Tobler and F. Müller (1997) The expression of the C. elegans labial-like Hox gene ceh-13 during early embryogenesis relies on cell fate and on anteroposterior cell polarity. Development 124: 4193-4200.
Goldstein, B. and G. Freeman (1997) Axis specification in animal development. BioEssays 19: 105-116.
		Goldstein, B. and S. N. Hird (1996) Specification of the anteroposterior axis in Caenorhabditis elegans. Development 122: 1467-1474.
		Goldstein, B. (1995) Cell contacts orient some cell division axes in the early C. elegans embryo. The Journal of Cell Biology 129: 1071-1080.
		Goldstein, B. (1995) An analysis of the response to gut induction in the C. elegans embryo. Development 121: 1227-1236.
Goldstein, B., S. N. Hird, and J. G.White (1993) Cell polarity in early C. elegans development. Development 1993 Supplement: 279-287.
		Goldstein, B. (1993) Establishment of gut fate in the E lineage of C. elegans: the roles of lineage-dependent mechanisms and cell interactions. Development 118: 1267-1277.
		Goldstein, B. (1992) Induction of gut in Caenorhabditis elegans embryos. Nature 357: 255-257.

Reviews of our work:

Faculty of 1000 review of "The Tardigrade Hypsibius dujardini, a New Model for Studying the Evolution of Development"

"And Water Bear It Is", from the DNA & Diversity column at ScientificBlogging

Faculty of 1000 review of "Segmental Expression of Pax3/7 and Engrailed Homologs in Tardigrade Development"

"Gastrulation: Wnts Signal Constriction", a Dispatch article about Lee et al. 2006, from Current Biology

Faculty of 1000 reviews of "Wnt/Frizzled Signaling Controls C. elegans Gastrulation by Activating Actomyosin Contractility"

"Tugging and pulling in asymmetric cell divisions" from J Cell Biol

Faculty of 1000 reviews of "Wnt Signals Can Function as Positional Cues in Establishing Cell Polarity"

"Bringing classical embryology to C. elegans gastrulation", a Preview article written by our hero Eric Wieschaus and colleagues, from Developmental Cell

"Microtubule cytoskeleton: Navigating the intracellular landscape", a Dispatch article about Labbé et al 2003 and four other new papers, from Current Biology

"Gastrulation: Partaking of the bottle", a Dispatch article about Lee & Goldstein 2003 and one other paper, from Current Biology

Faculty of 1000 reviews of "Mechanisms of cell positioning during C. elegans gastrulation"

"New & Notable: RNA Interference", from The Scientist

Faculty of 1000 reviews of "Using RNA Interference to Identify Genes Required for RNA Interference"

"UNC's Bob Goldstein talks about getting into RNAi and hunting for genes", from RNAi News

"RNAi to RNAi", from Genome Biology