Marc Nishimura
Education:
· Ph.D., Biology, 2005. Stanford University
· B.A., 1994. Vassar College
Project Description:
I am interested in understanding how the translocated effector proteins of the plant pathogen, Pseudomonas syringae, interact with the plant host to both promote virulence and determine host range. To this end, we have generated a large collection of effector proteins that covers the diversity of 16 strains of Pseudomonas. Experiments are underway to identify interacting host targets, to determine in planta subcellular localization of effectors and to demonstrate their contribution to pathogen virulence.
Publications:
Vorwerk, S., Schiff, C., Santamaria, M., Koh, S., Nishimura, M., Vogel, J., Somerville, C. and Somerville, S. 2006. EDR2 Negatively Regulates Salicylic Acid-Based Defenses and Cell Death During Powdery Mildew Infections of Arabidopsis thaliana. BMC Plant Biology (Submitted)
Nishimura. M.T., Stein, M., Hou, B.H., Vogel, J.P., Edwards, H., and Somerville, S.C. 2003. Loss of a callose synthase results in salicylic acid-dependent disease resistance. Science 301, 969-72.
Nishimura, M., and Somerville, S. 2002. Resisting attack. Science 295, 2032-33.
Somerville, S.C., Nishimura, M., Hughes, D., Wilson, I., and Vogel, J. 1998. Alternate methods of gene discovery -- the candidate gene approach and DNA microarrays. Pages 297-309 in: Cellular Integration of Signaling Pathways in Plant Development. NATO ASI Series, Vol. H104 (F. Lo Schiavo, R.L. Last, G. Morelli, and N.V. Raikhel, eds.). Springer-Verlag, Berlin.
Botella, M.A., Coleman M.J., Hughes D.E., Nishimura M.T., Jones J.D.G., and Somerville S.C. (1997). Map positions of 47 Arabidopsis sequences with sequence similarity to disease resistance genes. The Plant Journal 12, 1197-1211.