David Hubert
Education:
· Ph.D, Biology, 2007. University of North Carolina, Chapel Hill, North Carolina, Advisor: Dr. Jeffrey L. Dangl
· B.S., Biology, 2000. Indiana University, Bloomington, Indiana. General Honors Notation.
Project Description:
My work focuses on the genetic dissection of the RPM1 disease resistance gene pathway. A large part of this work involves the study of the RAR1/SGT1/HSP90 complex, and how these three proteins physically and genetically interact to maintain appropriate levels of R proteins. I am also currently in the process of characterizing and mapping newly identified mutants that either also affect RPM1 protein accumulation or affect RPM1 function without affecting RPM1 protein accumulation.
Publications:
Qutob D, Kemmerling B, Brunner F, Kufner I, Engelhardt S, Gust AA, Luberacki B, Seitz HU, Stahl D, Rauhut T, Glawischnig E, Schween G, Lacombe B, Watanabe N, Lam E, Schlichting R, Scheel D, Nau K, Dodt G, Hubert D, Gijzen M, Nurnberger T (2006) Phytotoxicity and innate immune responses induced by Nep1-like proteins. Plant Cell. 18, 3721-44.
Kawasaki, T, J Nam, D Boyes, BF Holt III, D Hubert, A Wiig, J Dangl (2005) A duplicated pair of Arabidopsis RING-finger E3 ligases contribute to RPM1- and RPS2-mediated hypersensitive response. The Plant Journal 44, 258-70.
Belkhadir, Y, Z Nimchuk, DA Hubert, D Mackey and JL Dangl (2004) Arabidopsis RIN4 negatively regulates disease resistance mediated by RPS2 and RPM1 downstream or independent of the NDR1 signal modulator, and is not required for the virulence functions of bacterial type III effectors AvrRpt2 or AvrRpm1. Plant Cell 16, 2822-2835.
Hubert, DA, P Tornero, Y Belkhadir, P Krishna, A Takahashi, K Shirasu and JL Dangl (2003) Cytosolic HSP90 associates with and modulates the Arabidopsis RPM1 plant disease resistance protein. EMBO J 22, 5679-5689.
Holt, BF III, DA Hubert, and JL Dangl (2003) Resistance gene signaling in plants—complex similarities to animal innate immunity. Curr Opin Immunol 15, 20-25.