Mail to Instructor: Sarah Grant
Answer Key: Midterm 1
Answer Key: Midterm 2
Answer Key Final Exam
Results to use for lab reports
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Aug. 25 Genes, Alleles and Epistasis
For review: Genes, and alleles, complementation : Hartl and Jones Chapter 3 pp. 90-112, Chi-square test pp. 162-165.
Aug 26/27 Lab 1: Mendelian Genetics using Fast Plants
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Please also look at the FastPlants web site: http://www.fastplants.org
Report due Sept. 9/10.
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Sept. 1 Labor Day - No lecture but labs will be held this week.
Sept. 2/3 Lab 2: Pipetteman and and Titration Exercise, Genes and Alleles in yeast.
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Readings from Manny, T., Davis, L., Johnson, B., Manney, M., Montelone, B., Weaver, L., and Williamson, B. 1997. A Classroom Guide to Yeast Experiments Kansas State University. Distributed by Carolina Biologicals.
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Reading - A Closer Look at Adenine-requiring Mutants in Yeast--
Report due Sept. 16/17.
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Sept. 8 Mouse Models and Epistasis.
For Review: Hartl and Jones pp. 112-125.
Sept. 11/12 Epistasis using mice
Report due Sept. 23/24.
Report on Mendelian Genetics Using Fast Plants due in lab this week.
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Sept. 15 Mutagenesis.
Powerpoint show
For Review: Hartl and Jones pp. 592-604, 612-636..
Reading - A Closer Look at Biological Consequences of UV exposure
Optional Reading Mouse mutagenesis: Du 2004
Optional Reading Mouse mutagenesis: Beutler 2005
Sept. 16/17 Mutation in Yeast.
Report due Sept. 30/Oct. 1.
Report on Genes and Alleles in yeast due in lab this week.
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Sept. 22 Bacterial Genetics.
.Powerpoint show
Reading to read before class and discuss in class: Lederberg and Tatum 1946.
For Review: Hartl and Jones pp. 344-369.
For interest: E. coli genome comparisons Brzuszkiewicz et al 2006
Pseudomonas syringae genome comparisons Chang et al 2005
Sept. 23/24 Bacterial Genetics.
Report due Oct. 7/8.
Report on Genes Alleles and Epistasis Lab due in lab this week.
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Sept. 29 C. elegans as a model system and epigenetics.
Powerpoint show:
For Review: Hartl and Jones pp. 558-562.
Sept. 30/Oct. 1 and Oct. 7/8 C. elegans genetics and RNAi.
Protocol amendments
Report due: Oct. 21/22
Report on Mutation Lab due in lab this week.
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Oct. 6 Midterm1 in class. Will cover up to Bacterial Genetics Lab and associated lecture material.
Oct. 7/8 C. elegans genetics and RNAi will continue.
Report due: Oct 21/22.
Report on Bacterial Genetics Lab due in lab this week.
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Oct. 13 Mapping the Huntington Gene.
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Powerpoint show
Readings for class: Hartl and Jones pp. 105-112, pp. 176-203.
Research Paper topics due in writing in class
Oct. 14/15 to Nov11/12 Drosophila Genetics.
Report on Drosophila lab due Nov. 25. ____________________________________________________________________
Oct. 20 DNA cloning.
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Powerpoint show
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For review: Hartl and Jones pp. 53-62, 502-518.
Oct. 21/22 Cloning Lab.
Report due: Nov 4/5.
Report on C. elegans lab due in lab this week.
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Oct. 27 Drosophila as a model system.
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Powerpoint show
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Readings for class: Hartl and Jones pp. 151-156, 194-198 (see Oct. 13), 565-580.
Outlines for research papers due in lecture period.
Oct. 28/29 Drosophila lab continues, test cross, score for sex-linked traits.
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Nov. 3 Association mapping for Human diseases Guest Lecturer: Karen Mohlke
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Reading: Hartl and Jones Chapter 18
Nov. 4/5 Association mapping lab
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Protocol.
Report due Nov. 18/19.
Report on Cloning Lab due in lab this week.
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Nov. 10 Midterm in class. Will cover up to Drosophila as a model system. Will not cover three-point cross.
Nov. 11/12 Drosophila lab continues, score results of test cross.
Report due Nov. 25/26.
No reports due this week. Work on your research paper!!!
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Nov. 17 DNA markers and Forensics. Read the first two papers posted on this page, below, before class and be ready to discuss in class.
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Powerpoint show
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Hartl and Jones pp. 62-79, 731-734.
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Reading - Lander and Ellis News and Views 1998.
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Reading - Foster et. al. 1998 Jefferson data
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Suggested Reading - Sobrino et al. 2005 SNP analysis methods
Nov 18/19 Forensics lab: Human DNA, PCR and variation
Report on Association mapping lab due this week.
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Nov. 24 Map-based cloning in model organisms.
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Powerpoint show
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Physical Mapping of genes: Hartl and Jones pp. 514-515, 518-521.
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Lewkowitz et al 2000 Plant Physiol. 123;795-805
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Szymanski et al 2000, Trends in Plant Science 5: 214-219
Research papers due in class Monday Nov. 24.
Report on Drosophila lab due this week.
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Dec. 1 Review.
Dec. 2/3 Map-Based Cloning Lab.
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Powerpoint show
Report on Forensics lab due this week.
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Dec. 8 Final Exam in 106 Gardner Hall 12:00 noon - 3:00 pm. Covers entire course.
