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Bio 202-007 Genetics and Molecular Biology Fall 2008 Tuesday, Thursday 11-12.15 Coker 201
"Ignorance more frequently
begets confidence than does knowledge: it is those who know little, and not
those who know much, Charles Darwin, The Descent of Man
"Do not be daunted by the enormity of the world's grief. You are not obligated to complete the work, but neither are you free to abandon it.” The Talmud
Dr. Jeff Dangl Coker 108A office hours: R 4.00-5.30 or appointment Web page: http://www.bio.unc.edu/faculty/dangl/
Dr. Kerry Bloom Fordham 623 office hours: T,W,R 1.00-3:30 or appointment Web page: http://www.bio.unc.edu/faculty/bloom/
Download a PDF of this Syllabus Download a PDF of “Useful tips for Bio 202 success”
TAs and Recitations (all Wilson 213):
Kristen Tamburro (tamburro@med.unc.edu)
701,702,707,708
Christian Burr (cburr@email.unc.edu)
703, 704, 705, 706
Text: Genetics: Analysis of Genes and Genomes, 6th Ed. DL Hartl and EW Jones; Pub: Jones and Bartlett
Lecture Schedule:
Lec. # Date Topic Reading HW? Lecturer
1 8.19 Introduction: Why Genetics? Review Chap. 1 (skim to review) Bloom Additional required reading: S. Weinberg “Four Golden Lessons” Nature (2003) 436, 389
2 8.21 Mendel I: transmission genetics Chap 2 pgs. 68-69 HW 1 Bloom Chap. 3 pgs. 88-112 pgs. 119-end
3 8.26 Mendel II: transmission genetics Chap. 3 as for lecture 2 Bloom
4 8.28 Chromosome theory, sex chromosomes Chap. 4 pgs. 134-159 HW2 Bloom
5 9.2 Chromosome Packing and Structure Chap. 7 pgs. 260-271 Bloom pgs. 274-end
6 9.4 Linkage and gene mapping, I Chap. 5 pgs. 176-198 HW3 Bloom
7 9.9 Linkage and gene mapping, II Chap. 5 as for lecture 6 Bloom
8 9.11 Linkage and tetrad analysis; Chap. 5 pgs, 203-end HW4 Bloom Mitotic recombination; The mechanism of recombination Chap. 6 pgs. 245-end Bloom
9.15 Review session, 7.30pm, Coker 201
9 9.16 First Exam (Covers lectures #1-7 inclusive, HW 1-3)
10 9.18 DNA Structure Chap 1 (skim to review pgs 1-20) HW5 Dangl Chap. 2, pgs. 46-53
11 9.23 DNA Replications, mutation and repair Chap. 6 pgs. 222-241 Dangl Chap. 14 pgs. 592-604 pgs. 612-622 pgs. 626-632
12 9.25 Transcription and Translation Chap. 10 pgs. 398-428 HW6 Dangl
13 9.30 Bacterial Genetics I: Chap. 9 pgs. 344-369 Dangl Transformation / Conjugation
14 10.2 Bacterial genetics II: Chap. 9 pgs. 365-end HW7 Dangl Transduction and Phage Genetics
15 10.7 Bacterial genetics III: Chap. 10 pgs. 428-end Dangl Phage Genetics and the Genetic code Chap. 14 pgs. 632-635
16 10.9 Gene Regulation I: Prokaryotes Chap. 11. pgs. 444-460 HW8 Dangl
10.13 Review session, 7.30pm, Coker Hall 201
17 10.14 Second Exam (Covers lectures # 8-15 inclusive, HW 4-7)
10.16 Fall Break
18 10.21 Gene Regulation II: Eukaryotes Chap. 11. pgs. 464-end Bloom
19 10.23 Chromatin and Epigenetics ?????? HW8 Bloom
20 10.28 Cell Cycle, and Cell Cycle gone wild: Cancer Chap. 15 pgs. 642-end Bloom
21 10.30 Chromosomal Abnormalities Chap. 8 pgs. 294-328 HW9 Bloom
22 11.4 Recombinant DNA I: Cloning, PCR, Sequencing Chap. 2 pgs. 53-69 Bloom Chap. 12 pgs. 500-515
23 11.6 Recombinant DNA II: DNA-based Genetic Chap. 2 pgs 69-end HW10 Bloom Maps, Genetic Testing Chap. 6 pgs 241-245 Chap. 12 pgs. 515-521
11.10 Review session, 7.30 pm, Coker 201
24 11.11 Third Exam (Covers lectures # 16-22 inclusive, HW8-10)
25 11.13 Genomics I: Whole Genome Sequencing Chap. 12 pgs. 521-end HW11 Dangl Power point slide show
26 11.18 Genomics II: Whole Genome Powerpoint slide show Dangl Sequencing and Gene Expression Profiling
27 11.20 Transgenic Organisms, Mice, and Stem Cells Power point slide show Dangl
28 11.25 Genomics and Personalized Medicine Power point slide show Dangl
11.22 Thanksgiving
29 12.2 Plants, Water, Society and You; and some fun Power point slide show Dangl
WED 12.10.2008 Review Session covers lecture dates 22-29
THURS 12.11.2008 8.00-11.00am Semi-Comprehensive Final Exam
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