Weinberg = The Biology of Cancer. Robert Weinberg

Angier = Natural Obsessions: The search for the oncogene.   Natalie Angier

(MP) = Mark Peifer  (BD) = Bob Duronio

 

Date:                 Lecture:

Jan. 10Basic properties of cancer cells/multigenic nature of cancer/basic genetics (MP)
Angier, pp 11-16.
Weinberg Chapt. 1, pp12-13, Chapt 2.1-2.5 (pp. 25-43), Chapt. 5.1 (pp. 119-123), Chapt. 11.1-11.5 (pp. 399-416)

 

Jan 15Viral oncogenes—the story of src (MP)
Angier pp. 65 (“But in 1975…”)-69
Weinberg Chapt. 3.1-3.3 (pp. 57-65), 3.5-3.13 (pp 69-90), Chapt. 5.2 (pp, 123-126), 5.8 (pp. 147-149)

 

Jan 17Current thoughts about src function (MP)
Weinberg Chapt. 6.3 (pp. 166-171)

 

Jan 22 The discovery of cellular oncogenes—the story of ras (MP)
Angier pp. 70-73 (“shooting at the breeze”), pp. 91-95; 96-116
Weinberg Chapt. 4.1-4.3 (pp. 91-99); Table 4.1; 4.4 (pp. 103-107), Chapt. 5.9 (pp. 150-153).

 

Jan 24 How did model organisms inform our understanding of ras function (MP)
Angier pp. 124 (“Bob Weinberg learned that…)- 129 (and I’m very proud to be able to say that.”)
Weinberg Chapt. 6.2 (pp. 164-165), 6.4-6.5 (pp. 171-176)

 

Jan. 29 Continued (MP)

 

Jan. 31 The EGF-receptor pathway and Herceptin therapy (MP)
Angier pp. 237-249; pp. 315 (in the wake of the shakeout..”)-323.
Weinberg Chapt. 4.3 (pp. 100-101), Chapt 5.3-5.6 (127-140), Chapt. 16.1-16.5 (725-746), 16.12 (pp. 765-769)

 

Feb. 5 Exam (Material through 1/31)

 

Feb. 7 Basic properties of the cell cycle as determined by studies in model organisms (BD)
Weinberg Chapter 8, pages 255-262.

 

Feb. 12 Cell cycle control via cyclin/cdk's and cdk inhibitors (BD)
Weinberg Chapter 8, pages 262-273.

 

Feb. 14 Growth factors and growth control and the influence on cell cycle regulation (BD)
Weinberg Chapter 10, pages 357-367.

 

Feb. 19 Basic properties of tumor suppressors—the story of pRB (BD)
Weinberg Chapter 7, pages 209-221.

Angier pp. 304 - 315 ("... his brightest  hopes."), pp. 324-373.

 

Feb. 21Current thoughts about pRB function (BD)
Weinberg Chapter 8, pages 273-284.

 

Feb. 26Current thoughts about pRB function continued (BD)

                        Weinberg Chapter 8, pages 296-298.

 

Feb 28 First session devoted to student presentations

 

March 4Exam 2 (Material through Feb 26)

 

March 6 Student presentations

 

March 11 Spring Break

March 13 Spring Break

 

March 18 Sessions devoted to student presentations

March 20 (continued)

March 25 (continued)

March 27 (continued)

April 1 (continued)

April 3 Guest lecture

 

April 8 Chromosomal rearrangements—abl and oncogenesis (MP)
Weinberg p.112, Chapt. 16.6-16.11 (pp. 747-765).

 

April 10 Abl’s diverse cellular functions—new treatments (MP)

 

April 115 Family studies to identify tumor suppressors—the APC story (MP)
Weinberg Chapt. 6.10 (189-191), Chapt 7.11 (pp. 235-241).

 

April 17 Cell cycle checkpoints: What are they for? (BD)
 

April 22 Apoptosis and tumor suppression—the story of p53 (BD)
Weinberg Chapter 9, pages 307-317.

 

April 24DNA damage and cancer—Current thoughts about p53 function (BD)

                        Weinberg Chapter 9, pages 317-333.

 

Tues. April 29 12:00 pm Exam 3 (Final)

last updated 12/29/2007