Models of Human Disease

Shawn Ahmed: Telomerase and cancer, proliferative aging

Albert S. Baldwin:  NF-kappaB in cancer, HIV infection, immunity and inflammation

Victoria L. Bautch: Mouse models of cancer and diabetes

Frank Conlon: Animal models and mechanism of human congenital heart disease

Robert J. Duronio: A model genetic system for studying the retinoblastoma tumor suppressor pathway

Sarah R. Grant: The type III secretome, a virulence mechanism shared by plant and human pathogens.

Alan M. Jones:  A model system for studying sugar (diabetes) and extracellular nucleotide (cystic fibrosis) sensing

Greg Matera: Mouse and fruitfly models of Spinal Muscular Atrophy

Ann G. Matthysse: Mechanisms by which human pathogenic E. coli recognize and bind to plant surfaces

Steven W. Matson:  Mechanisms of DNA mismatch repair

Mark Peifer: Model systems to study the tumor suppressor APC and the oncogene Abl

Steve Rogers: A model system for understanding chromosomal instability and cell migration

Ted Salmon: The genetic basis for aneuploidy in cancers; function of the spindle checkpoint protein BubR1

Kevin Slep: Perturbations of cytoskeletal function: aberrant mitotic events in cancer

Darrel W. Stafford:  A mouse model to study hemophilia B and evaluate gene therapy for it

Jeff Sekelsky: Models of premature cancer syndromes