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The research in our lab is currently funded
by the following sources:
2007-2011 Comprehensive Identification of Active
Functional Elements in Human Chromatin
NIH/NHGRI
U54 (Crawford PI, Lieb Subcontract)
The goal of this proposal is
to identify at high resolution all active gene regulatory elements in the
human genome among cell types representative of most human tissues by
identifying regions of open chromatin with FAIRE and DNase hypersensitivity
assays
2007-2011
Identification of DNA Elements Governing Chromatin Function in C. elegans
NIH/NHGRI 1
U01 HG004270 Lieb (PI)
Written in response to the
“modENCODE” RFA, this grant includes 7 co-investigators and aims
to identify discrete elements that regulate chromatin structure and function
in the nematode C. elegans.
2005-2010
Genomic Approaches to DNA-binding Specificity in vivo
NIH/NIGMS R01 GM072518. Lieb (PI)
These
experiments aim to determine the mechanistic relationship between
transcription, chromatin organization, and DNA-binding site utilization in Saccharomyces cerevisiae.
2006-2008
Regulation of Nucleosome Stability as a Mediator of Chromatin Function
North Carolina Biotechnology Center Award
2006-MRG-1107
Strahl (PI),
Lieb (Co-PI)
To test our
hypotheses regarding nucleosome stability and its relationship to chromatin
function, we propose a novel interdisciplinary approach that combines
genetic, biochemical, cytological and biophysical experiments with the use of
multiscale computational modeling of nucleosomal chromatin. This proposal centers
on the histone variant Htz1.
Completed
Funding:
2004-2007
STAGE and FAIRE for Regulatory Element Identification
NIH/NHGRI 5
R01 HG 3532-2 Iyer (PI), Lieb (Co-PI)
The
objective of this proposal is to develop and combine two entirely new genomic
technologies for identifying functional elements in the human genome. In
response to RFA HG-04-001, “Technologies to find functional elements in
genomic DNA”.
2005-2006
Rationalization of Gene Regulation by Genome Analysis
NIH/NIGMS 5
R01 GM065179 Clarke (PI), Lieb
(Subcontract)
Our lab
performed chromatin-IP microarray experiments under a subcontract to NIH
grant GM065179 in an effort to quantitate the effects of chromatin and
context on DNA binding site utilization.
2002-2005 National Human Genome Research Institute Genome
Faculty Transition Award.
NIH/NHGRI
K22 1 K22 HG002577. Lieb (PI)
NHGRI
Genome Faculty Transition Award enables promising researchers to establish an
independent program in genomic research and analysis.
2002-2004 The V Foundation for Cancer Research
Scholar
Total
Direct Costs: $100,000. Lieb (PI)
The
V Scholar grant provides funding to young investigators to pursue basic
research in cancer biology.
The laboratory has also been
supported by start-up funds provided by the Department
of Biology and the Carolina Center for
Genome Sciences.
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